Vince is described as an aging rock star whose popularity and success is on the decrease, however, he is trying to make a come-back. Vince had a sister named Wendy Vincente and she was stricken with paralysis.
At some point, Vince began dating a woman named Jen. Their relationship suffered due to Vince's constant abandonment of her. Jen left Vince as a result, and later committed suicide. Vince came to regret this loss for many years after.
Vince and his bandmates perform a successful show, and Vince is shown proud alongside his team. However, backstage reveals that Vince is feeling depressed as he drinks and stares at a picture of his late lover. His bandmate Tommy suggests Vince joins the team on a fun night in Cleveland, but Vince declines.
Vince returns to his apartment looking exhausted. He goes to the sink to wash his face but gets covered in blood. He begins to panic, even more when things in his room start flying around.
He tries to call for help but the phone is dead. When Vince escapes into another room, he is confronted by Jen, much to his surprise. "Jen" apologizes for leaving him the way she did, describing her suicide as selfish but at the time, Vince deserved it.
Vince admits he would do anything to have her back, and "Jen" tells him he can. "Jen" reveals she is a powerful angel who can take away his pain and grant him peace, and that all Vince needs to do is to let her in.
The grief-stricken Vince accepts, and his consent allows him to be possessed by the archangel Lucifer.
In The Foundry, Lucifer heals Vince's sister Wendy of her paralysis as part of the agreement he made to get Vince's permission. He also starts burning through Vince so he asks Rowena to cast a spell to make Vince into a more permanent vessel. Instead, Rowena casts a spell to speed up the decay of Vince's body and banishes Lucifer to the bottom of the ocean.
In Rock Never Dies, a couple of amateur Satanists attempt to summon Lucifer using one of his feathers taken from one of Lucifer's Crypts. Lucifer appears in the form of a deformed Vince and uses the feather to temporarily heal himself before killing the Satanists. Posing as Vince, Lucifer reunites his band in order to have a concert where he will kill everyone. Lucifer kills all of Vince's band but Vince starts to decay once more. As Vince burns out, Lucifer departs his body in a stream of light, leaving Vince a dead shriveled-up husk.
Sam later states that they didn't win as Vince and other people still died. When Dean points out that they had no hope of saving Vince, Sam tells him Lucifer took everything Vince was and twisted and destroyed it. Following Vince's death, his body is taken away in an ambulance and the news reports on his death.
- Season 12
- In some way, Vince's life description mimics that of Lucifer. The Archangel is trying to make a come-back himself, after abandoning malevolence.
- Strangely, despite this description given by the crew, Lucifer has gone back to malevolence out of spite towards God.
- The method Lucifer uses to manipulate a "yes" out of Vince resembles the method he used on Nick, by taking the form of a woman whom they loved and lost and promising salvation in return for their consent.
- Vince's death also mirrors Nick's. Both of them died from being unable to contain Lucifer for very long. However, it should be noted that Nick lasted at least six months while Vince died within a month.