I don't know how much of a stickler thee are for Biblical prophecies, but thou may hast noticed in thy televised show Supernatural thou hast come across Biblical references. So it makes sense for these prophecies to have been fulfilled:
"The Beast has seven heads and ten horns, and the seven heads of the Beast represent seven kings. Of the seven five have fallen, one is, the other has not yet come. The eighth is a king of the seven, who is going to his destruction."
This could be taken as meaning angels and Archangels. There are four Archangels. Four have fallen. Put good old Zach in there and thee have "five that have fallen." One, Castiel, "is." The other, Metatron, "has not yet come." The eighth is Castiel, "who is a king of the seven, but is going to his destruction."
The star Wormwood was War, as we saw when the Winchesters went off to film Animal Planet. As for the two Beasts, they would represent Lucifer and Dick Roman, "Christ defeats them and throws them in the Lake of Fire for eternity."
...And now we are left to ponder what Sam Winchester is doing in Sucrocorp's labs and if he made good on his promise to strip for Castiel.