This era introduces a new central character, the nephilim Jack Kline, son of Lucifer. Having the potential to surpass the powers of an archangel, Jack's existence has caught the attention of different organizations, major powers, and, even beings from alternate realities and dimensions. Sam, Dean and Castiel took Jack under their wing, fending off multiple enemies while also ensuring Jack learns to control his powers and use them for good. The interactions between alternate universes eventually culminate into the intervention of cosmic powers Billie as the new Death, the Shadow, the Darkness, and a confrontation with God.
|“||If Season 12 was about children coming to terms with their moms as adults, then Season 13 is very much about Sam and Dean as parents.||”|
— Andrew Dabb 
|“||What's bigger than God? The answer is nothing. So after we did that, it was really about new directions that we could take our characters that will give them new things to react to? This opens up a lot of storytelling ideas in that way.||”|
— Andrew Dabb on the alternate universe in Season 13 
|“||I think Season 14 is going to be a little less broad in scope and a little more emotional, more personal stories about the guys.||”|
— Robert Singer on Season 14 
|“||Firstly, we would like to thank all the people who have been involved with the show both in front of and behind the camera. For us it has been an experience of a lifetime. The support we have had from both Warner Bros Television and The CW has been incredible. We'd like to give special thanks to Jensen, Jared and Misha for making this journey so special. It is now most important to us to give these characters that we love the send off they deserve.||”|
— Robert Singer and Andrew Dabb on the final season
Sam and Dean come up against the British Men of Letters and their plan to wipe out the hunters. Meanwhile, with the help of Castiel and Crowley, they have to face Lucifer, and come to terms with the return of their mother Mary.
With Castiel, Crowley, Kelly and Rowena dead, Sam and Dean are left to look after Lucifer's son Jack while they try to retrieve Mary from the Apocalypse World and protect their world from an Alternate Michael and the new King of Hell Asmodeus.
God has opened up Hell, releasing the damned souls within. Sam, Dean and Castiel face off against their toughest foe yet while also dealing with the death of Jack and the return of their half-brother Adam.