Sera Gamble is the showrunner of a television series called Supernatural, which narrated the life of Sam and Dean Winchester, but only as a narrative fiction. Sam and Dean encountered the series and its set and producers when Balthazar sent them into the alternate reality to keep Virgil, and by extension, the archangel Raphael, from taking hold of Heaven's Weapons. She became showrunner after the departure of the creator and original showrunner, Eric Kripke.
When Sam and Dean attempted to replicate the spell performed by Balthazar, Sera, along with the other staff of the show, planned to have the two be counselled by Eric. However, Virgil's arrival brought death upon many of the show's staff.