Season 6 consists of 22 episodes. Creator Eric Kripke originally planned for the show to last only five seasons, but due to increased ratings from the fourth and fifth seasons, the CW network renewed the series for a sixth season. Kripke has not returned as showrunner, but still remained as a hands-on executive producer, leaving executive producer Sera Gamble to take over the reins.
The sixth season begins a year after the end happenings of the fifth with Dean Winchester living a happy life with Lisa and Ben Braeden. Sam returns to the world of the living and teams up with Dean, who leaves his new life behind. Sam Winchester has been working under Samuel Campbell in order to hunt and capture alive Alpha monsters (first of the gene pool). Castiel is barely helpful anymore because the civil war in Heaven has taken its toll. It is discovered that Samuel is following Crowley's orders in exchange for the return of his daughter. Crowley wants to use the Alphas to locate Purgatory, in which there are a vast collection of souls that could be used for power. Crowley brought back Sam without his soul, and Dean implores the help of the Horseman Death in order to retrieve it. Death puts a wall up in Sam's mind so that he will not remember Hell. The old Sam returns with no memory of the past year. It turns out Castiel made a deal with Crowley for each of them to receive half of the souls in Purgatory. Dean doesn't like the idea and tries to stop the duo. To stop the Winchester brothers and Bobby Singer, Castiel knocks down the mental barrier in Sam. Castiel betrays Crowley, Crowley becomes allies with Raphael and performs the ritual to open the doors of Purgatory. It fails because they had fake dog's blood and Castiel appears full of power from having done the ritual himself. He obliterates Raphael and Crowley escapes. When the Winchesters try to talk Castiel into reason, he reveals that he is not an angel anymore, he has become the new God.
- Jared Padalecki as Sam Winchester (22/22)
- Jensen Ackles as Dean Winchester (22/22)
- Misha Collins as Castiel (12/22)
- Jim Beaver as Bobby Singer (12/22)
- Mark A. Sheppard as Crowley (8/22)
- Mitch Pileggi as Samuel Campbell (7/22)
- Cindy Sampson as Lisa Braeden (7/22)
- Sebastian Roché as Balthazar (6/22)
- Nicholas Elia as Ben Braeden (5/22)
- Demore Barnes (2/22) and Lanette Ware (2/22) as Raphael (4/22)
- Jessica Heafey as Gwen Campbell (4/22)
- Corin Nemec as Christian Campbell (4/22)
- Julia Maxwell as Eve (3/22)
- Kim Johnston Ulrich as Dr. Visyak (3/22)
- Steven Williams as Rufus Turner (2/22)
- Rick Worthy as Alpha Vampire (2/22)
- David Paetkau as Mark Campbell (2/22)
- Sonya Salomaa as Rachel (2/22)
- Laura Mennel as Brigitta (2/22)
Episode List: 2010-2011
|Exile on Main Street||Writer: Sera Gamble||Director: Phil Sgriccia||09/24/10||#105 601|
|It’s a year later and Dean has given up hunting and is living with Lisa and her son Ben. Mysteriously freed from his cage in hell, Sam finds Dean and tells him he needs to rejoin the fight and introduces Dean to a world—a family—he never even knew existed.... the Campbells, his mother’s family, lead by none other than their Grandfather Samuel.
|Two And A Half Men||Writer: Adam Glass||Director: John F. Showalter||10/01/10||#106 602|
|Sam investigates a case about missing babies whose parents are being murdered. At one of the crime scenes, he discovers a baby that was left behind and calls Dean for help. Reluctant to leave Lisa and Ben, Dean finally agrees to meet Sam and surprises his brother with how parental he has become.... The brothers take the baby to Samuel, who decides to raise it as a hunter, which infuriates Dean. However, before they can decide the baby’s future, a shape-shifter breaks in and attempts to kidnap the baby.
|The Third Man||Writer: Ben Edlund||Director: Robert Singer||10/08/10||#107 603|
|Sam and Dean call Castiel for help when they investigate a case about several dead police officers who seem to have been killed by the plagues of Egypt. Castiel confirms the staff of Moses was used to kill the cops and tells Sam and Dean that Heaven is in a state of chaos and God’s weapons have been stolen. The three head off to find the thief and come face to face with an old enemy.
|Weekend At Bobby's||Writer: Andrew Dabb & Daniel Loflin||Director: Jensen Ackles||10/15/10||#108 604|
|After Bobby discovers Crowley has no intentions of returning Bobby's soul, the hunter takes matters into his own hands. He calls on Sam and Dean for help after he unearths one of Crowley's deepest secrets. Meanwhile, Sam and Dean learn what Bobby does all day when they are not around.
|Live Free or Twihard||Writer: Brett Matthews||Director: Rod Hardy||10/22/10||#109 605|
|After a group of young girls go missing; Sam and Dean realize that a group of vampires have taken up residence in the small town. After a fight with two of the blood-suckers, Dean is bitten and turns into a vampire... Samuel tells Dean he can change him back but he’d have to get the blood of the vampire who turned him. Dean infiltrates the nest and runs into the Alpha...
|You Can't Handle The Truth||Writer: Eric Charmelo, Nicole Snyder & David Reed||Director: Jan Eliasburg||10/29/10||#110 606|
|Sam and Dean investigate a series of suicides and discover the victims were being told brutal truths that drove them crazy. They find out someone is invoking the Goddess of Truth, Veritas, forcing people to be cruelly honest against their will and Dean is the next victim. Dean is forced to tell Sam the truth about how he feels about his return from Hell.
|Family Matters||Writer: Andrew Dabb & Daniel Loflin||Director: Guy Bee||11/05/10||#111 607|
|Dean becomes suspicious of Samuel’s motives, but Sam isn’t sold on the idea that their grandfather is doing anything wrong. The brothers go along on a hunt with Samuel and the other Campbells, but things go terribly awry.
|All Dogs Go To Heaven||Writer: Adam Glass||Director: Phil Sgriccia||11/12/10||#112 608|
|Dean and Sam investigate what seems to be a werewolf killing but turns out to be a skinwalker posing as a family dog who is taking revenge on his owner’s enemies. After capturing the dog, he turns human and tells Sam and Dean that an Alpha skinwalker has created many sleeper cells that will rise on his command and kill their families.. The only way to stop the mass murders is to find and kill the Alpha.
|Clap Your Hands If You Believe||Writer: Ben Edlund||Director: John F. Showalter||11/19/10||#113 609|
|While Sam and Dean are investigating a UFO sighting, Dean is abducted from a crop circle. However, when he awakens, he discovers he isn't dealing with aliens, but fairies! Unfortunately, only Dean can see the fairy that keeps attacking him which makes tracing and stopping them difficult. The brothers become even more perplexed when Sam's investigation leads them to a world full of elves, gnomes and a leprechaun.
|Caged Heat||Writer: Brett Matthews & Jenny Klein||Director: Robert Singer||12/03/10||#114 610|
|Meg kidnaps Sam and Dean and tries to force them to tell her where Crowley is hiding. Sam makes her a deal they will help her find Crowley if she promises to torture him for information about how to get Sam’s soul back. Castiel joins the fight but finds it difficult to work with Meg.
|Appointment In Samarra||Writer: Sera Gamble & Robert Singer||Director: Mike Rohl||12/10/10||#115 611|
|Dean seeks out Death to help get Sam's soul back. Death tells Dean he will help Sam if Dean will agree to act as Death for 24 hours. Meanwhile, Sam decides he doesn't want his soul back and asks Balthazar for a protective spell to keep his soul out of his body. Balthazar tells Sam he needs the blood of his father for the spell to work and since John Winchester is dead, Sam decides Bobby is the next best thing.
|Like A Virgin||Writer: Adam Glass||Director: Phil Sgriccia||02/04/11||#116 612|
|Dean and Bobby anxiously wait for Sam to wake up to see if Death was able to restore his soul without causing Sam to lose his mind. Meanwhile, Dean and Bobby investigate a disappearance of virgins and discover dragons are behind the kidnappings. Bobby sends Dean to a doctor who owns the only weapon in the world that can slay a dragon, but Dean must prove himself worthy enough to take it.
|Unforgiven||Writer: Andrew Dabb & Daniel Loflin||Director: David Barrett||02/11/11||#117 613|
|Sam starts to have flashbacks to a case he worked on with Samuel before he reconnected with Dean. Sam receives a mysterious text with coordinates to a small town, so the brothers decide to investigate. Dean is surprised when the townspeople start telling him some of the things Sam did while he lived there.
|Mannequin 3: The Reckoning||Writer: Eric Charmelo & Nicole Snyder||Director: Jeannot Szwarc||02/18/11||#118 614|
|Ben calls Dean and tells him Lisa is in trouble. Dean leaves Sam to investigate a case alone and rushes home to rescue Lisa, however, he’s not prepared for what meets him at the door. Meanwhile, Sam discovers the men that were murdered were all a part of a cruel practical joke played on a female co-worker who went missing.
|The French Mistake||Writer: Ben Edlund||Director: Charles Beeson||02/25/11||#119 615|
|Raphael launches an attack on Castiel and his allies, sending a particularly frightening angelic hitman after Balthazar, Sam and Dean... In an effort to protect the brothers, Balthazar sends them to an alternate universe where they are the stars of a TV show called “Supernatural” and they are actors named “Jensen Ackles” and “Jared Padalecki.” The brothers are confused when Castiel appears to be a tweet-happy actor named Misha Collins and Sam is married to Ruby.
|...And Then There Were None||Writer: Brett Matthews||Director: Mike Rohl||03/04/11||#120 616|
|Sam, Dean and Bobby set out in search of The Mother of All’s latest monster. While investigating, they run into Samuel and Gwen, who are also hunting the creature. Samuel and Bobby get into a heated fight about how to handle the case.
|My Heart Will Go On||Writer: Eric Charmelo & Nicole Snyder||Director: Phil Sgriccia||04/15/11||#121 617|
|After Balthazar changes history and keeps the Titanic from sinking, Fate intervenes and begins killing those that would have died on the ship. Castiel tells Sam and Dean that Fate is very upset with the two of them and the only way they can stay alive is to kill her.
|Frontierland||Writer: Andrew Dabb, Daniel Loflin & Jackson Stewart||Director: Guy Bee||04/22/11||#122 618|
|While searching for a way to defeat Eve, Dean stumbles upon Samuel Colt’s journal in the Campbell library. Realizing Samuel might have the answer to their problems, Sam and Dean ask Castiel to send them back in time so they can meet the man himself. While Sam is a bit reluctant to time travel, Dean is beside himself with excitement to return to the Wild, Wild West.
|Mommy Dearest||Writer: Adam Glass||Director: John F. Showalter||04/29/11||#123 619|
|Sam, Dean, Bobby and Castiel track Eve to a small town in Oregon. The guys discover the townspeople have been converted to demons, but surprisingly, they all appear to be dying. When they finally do meet Eve, she decides to torture the brothers by bringing back their mother, Mary Winchester, as a demon.
|The Man Who Would Be King||Writer: Ben Edlund||Director: Ben Edlund||05/06/11||#124 620|
|Castiel tells his story about the war in Heaven and how he and Raphael became enemies. Bobby believes Castiel is hiding something while they look for Crowley, but Dean refuses to believe it.
|Let It Bleed||Writer: Sera Gamble||Director: John F. Showalter||05/20/11||#125 621|
|A demon kidnaps Ben and Lisa to get to Dean. Sam and Dean are forced to join with an unlikely ally to free them.
|The Man Who Knew Too Much||Writer: Eric Kripke||Director: Robert Singer||05/20/11||#126 622|
|The wall comes down in Sam’s head and all hell breaks loose. Dean and Bobby are, for once, at a total loss on how to help him and are forced to stand by and do nothing while Sam breaks. The battle for heaven comes to a head.