Following the Apocalypse, the San Antonio colony was one of the few remaining human colonies on Apocalypse World and had four hundred people living in it. Like all of the other colonies, it was a target for angels in the war of genocidal extermination.
In late 2017, the colony was "dive bombed" by angelic attackers. The angels destroyed the colony and killed every single person in it. The destruction was learned of by Bobby Singer's colony.
Two days after the destruction of the San Antonio colony, Bobby told Mary Winchester and Jack about the destruction of the San Antonio colony while explaining the atrocities the angels were committing and how his own colony was one of the last human settlements on the planet.