There was a -- whatever you want to call it -- a "rabid" attacking the closet door, and he just died. These things have a shelf life...

Rabids, named by Sam Winchester, were a new kind of creature created by the Darkness by corrupting humans. The corruption caused a mutation and made their behavior become aggressive, while still having a certain degree of intelligence. They can be cured by exposure to Holy Fire.



A group of rabids.

When the Darkness was released, she swept over the town of Superior, Nebraska where a road crew was infected and turned into Rabids. Some of the road crew attacked and killed a family that was on their way into town before being killed by Deputy Jenna Nickerson. More of the road crew made their way into town where they slaughtered everyone at a nearby hospital and started infecting the town. A few hours after the infection began, Sam and Dean Winchester came to the scene of the family's slaughter and encountered an infected member of the road crew who was still alive. They learned of the situation and went to the hospital where they found the slaughter there and learned that Rabids only have a limited lifespan.

After they take the baby Amara from her infected father, Dean promises to get her to safety with Jenna's help while Sam insists on remaining behind to attempt to find a cure for the Rabid infection. As Rabids surrounded the hospital, Sam distracted them while Jenna and Dean made a run for it. In the process, Sam killed a Rabid and got splashed with its blood, infecting him. Now infected, Sam began a search for a cure in earnest, capturing a Rabid that was still capable of speaking for more information. However, Sam's efforts to find a cure were in vain until he remembered that a Reaper named Billie told him that he was "unclean in the biblical sense." Looking up purifications from the Bible, Sam found references to fire and holy oil. Near being consumed by his infection, Sam held a sponge doused in holy fire near his neck, burning away the Rabid infection.

Now with a viable cure, Sam lured a group of Rabids into the hospital chapel where he encircled them in holy fire. The proximity to the holy fire cured the Rabids and the group and Sam went on to cure the surviving infected residents of Superior.


Months after the first outbreak, Amara unleashed a new kind of rabid that went on to infect anyone who made contact with the giant fog she sent. Hope Springs, Idaho was hit by this fog, a location Sam and Dean were also investigating at. According to one of the victims, this fog will harm all but Amara and Dean.

The outbreak was stopped by the direct interference of God, who cured all those infected, removed the fog entirely and resurrected all those who had died.

A short time later, Amara hit the town of Lewis, Oklahoma with her fog, causing the people to go Rabid and die. Thousands of people were killed with the only survivor being Donatello Redfield who became a Prophet. In this case, the Rabid infection seemed to quickly consume and kill the victims rather than taking time. When the Winchesters discovered this, God stated that he couldn't respond to this sort of attack every time and Amara was just trying to draw him out.


Rabids had black veins running across their neck and head, similar to when the Leviathan took control of Castiel's vessel. While they had increased aggression, they do not appear to be mindless, as they have been shown to have enough capacity to drive vehicles. One still retained enough humanity to name his daughter and let her go despite being moments from death.

When capturing a Rabid, Sam asked if the Rabid could talk or if he was "too far gone", indicating that they can retain their minds to a degree at least under the infection before losing it completely. They also appear to have a pack mentality, as when Sam was cornered by three of them, rather than go for the kill, two of them held him while a third detected that he had been infected. Another infected person told Sam that rabids can smell other rabids.

The mutation had a shelf-life which varied by person, but the infected would die hours after fully succumbing to it. If another rabid was detected, or a newly infected human, rabids would not attack. The rate of infection differed from person to person: one Rabid told Sam that "this thing, it ain't math" and "I've seen some people change fast, some change slow. But in the end we all end up the same: we go psycho and we go boom." The start of the infection happens very quickly as Sam was splashed with Rabid blood and moments later a pack of Rabids sensed him as one of them.

As a Rabid's infection progressed, the blackness in their veins was shown to travel from near their shoulder up their neck and face with the further the blackness has spread indicating how far along the infection is. Being "unclean in the biblical sense", rabids could be cured through proximity to holy fire to the point that even being trapped in a circle of it can cure them.

When Amara hit the town of Lewis, Oklahoma with her fog, the people went Rabid and died within a matter of hours at most, maybe even less. Donatello Redfield, the only survivor, witnessed people developing the black veins of a Rabid and dying. This was in contrast to the earlier Rabid outbreaks where people lived much longer before dying, suggesting that Amara had refined the infection. Donatello's cat died during the outbreak as well, indicating that the infection may have harmed animals as well that time at least.

Powers and AbilitiesEdit

  • Aggression - They are very aggressive and were agitated if there were humans nearby.
  • Infection - They can infect normal humans through contact with their blood. Just being splashed in the face with a Rabid's blood is enough to infect a person.
  • Super Senses - Rabids are able to smell each other and other regular humans who have been just infected.
  • Telepathy - The kind of Rabid appearing in Don't Call Me Shurley share a telepathic link with the Darkness.



Sam uses Holy Oil to cure himself.

  • Heart - A shot to the heart killed a rabid.
  • Throat - A slit throat killed a rabid.
  • Shelf life - Within a matter of hours after turning rabid, a rabid will die. The amount of time varies from person to person.
  • Holy Fire - Proximity to holy fire will cure a rabid.
  • Electrocution - A rabid is vulnerable to electrocution with a minor shock from a makeshift cattle prod rendering one unconscious.
  • God - God is capable of effortlessly curing an entire town of Rabids as well as easily suppressing the infectious fog that created them.

Known RabidsEdit



  • This is the first species that Sam has named.
  • The disease is similar to the Croatoan Virus: both were spread through the blood, increased aggression and encouraged infection without making the victim suffer from a hunger for human flesh, and neither granted victims enhanced combat abilities. Like the original Croatoan victims, rabids retained human intelligence (albeit limited to what was necessary to spread the infection) and worked in teams.
  • Rabids are among the few supernatural creatures not to demonstrate superhuman strength and resilience. Given their "shelf life" they are even more fragile than humans.
  • The rabids somewhat have similar appearance to humans possessed by Leviathans or angels infected by Leviathans' poisons.
  • Besides vampires and werewolves, Rabids are the only known monster type to have a cure. Castiel was able to cure Dean of being a Jefferson Starship, but he was powered by 50,000 souls at the time.
  • Like vampires, rabids reproduce via sharing blood.
  • Despite being created by the Darkness which is pre-biblical, the Bible contains a cure for the Rabid infection. However, as this is a biblical purification, it is likely just a coincidence and worked due to the Rabids being "unclean in the biblical sense."
  • Rabids have a striking similarity with Cranks from the Book Series of The Maze Runner. They both have a gradual transformation, whereas they slowly lose their sanity or control over themselves and eventually become zombie-like creatures. This is further similar as Sam said "or are you far too past gone?" to another rabid infected man in the episode Form and Void.
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