Louise is first seen passing by Sam and Dean as they leave the motel to go get the Alpha Vampire's blood. Later, after Emily has left and warned the Alpha Vampire of the Winchesters, Louise comes into their room and see Bobby's ghost who is extremely angry, having seen Dick Roman on the TV and trying but failing to open the safe where Dean has put his flask. Bobby suddenly realizes the combination is his birthday and asks Louise for help. When she runs away, he jumps into her body and, as he bleeds ectoplasm, says he only needs it for a little while. Bobby then opens the safe, grabs the flask, and heads on out to find Dick.
Later on, Bobby, still in Louise's body, sees Dick on a TV on display in a store's window. He goes to a shop and purchases a machete, then attempts to steal a truck. When he touches an iron chain in the truck, his spirit is forced out of Louise's body. She begs him to let her go, but Bobby spots a newspaper article about Dick, who's being called "Man of the Year." He becomes very angry again, and repossesses her. Later, while Sam and Dean check the cameras at SucroCorp for Dick, Sam sees Louise show up and he recalls seeing her at the motel in Hoople. He realizes it's Bobby and tries to stop him from being seen and 'going vengeful.' Bobby swings at Sam with the machete, and starts to choke him, but sees his reflection in a windshield and realizes what he's doing. He then gets out of Louise's body and disappears. Sam picks her up and the brothers take her to a hospital.