Beings killed by Lucifer.
Angels
Seraphim
- Castiel - Stabbed through the back with an angel blade; resurrected by the Cosmic Entity.
Cherubim
- Unnamed Cherub - Punched a hole through his chest after stealing his grace.
Regular Angels
- Castiel - Exploded at the molecular level in revenge for hitting Michael with holy fire; resurrected by God as a Seraphim.
- Angel Commander - Exploded at the molecular level.
- Nithael - Exploded at the molecular level.
- Four alternate reality angels - Exploded at the molecular level.
- Jofiel - Exploded at the molecular level.
Demons
Regular Demons
- Castiel and Lucifer's Attackers - Killed alongside Castiel in Crowley's old lair.
- Around a dozen demons - Sacrificed as part of a ritual to summon Death.
- Thomas and his friend - Exploded both at the molecular level.
- Rachel Nave and several other demons - Killed by Lucifer to give Sam revenge for the demons spying on him his whole life under the orders of Azazel.
Humans
Hunters
- Alternate reality hunter - Punched his fist through his body.
- Bobby Singer - Neck snapped with telekinesis; resurrected by Castiel. Killed again by Dick Roman.
Vessels
- Archbishop - Burned out through possession.
- Unnamed family of five - Burned out through possession.
- Nick - Burned out through possession.
- Jimmy Novak - Killed when Lucifer exploded Castiel.
- Gabriel's vessel - Killed when Lucifer killed Gabriel. Currently alive by unknown means.
- Vince Vincente - Burned out through possession.
- Wallace Parker - Burned out through possession.
Witches/Magic Practitioners
- Rowena MacLeod - Neck snapped; resurrected through a spell; killed again by stomping her head in and then incinerating her body; resurrected again by her spell.
Regular Humans
- A US Secret Service agent - Induced an aneurism.
- Gordy and Adam - Necks snapped with telekinesis.
- Priests and nuns of St. Louis, Missouri - Brutally slaughtered.
- Residents of Carthage, Missouri - Sacrificed as part of a ritual to summon Death.
- Russel Lemmons - Telekinetically stabbed with a pen.
- Tommy - Neck snapped with telekinesis.
- Vince's band mates - Necks snapped with telekinesis.
Other
Deities
- Baldur - Punched through the chest.
- Ganesh - Exploded at the molecular level.
- Isis - Brutally slaughtered.
- Odin - Brutally slaughtered.
- Baron Samedi - Brutally slaughtered.
- Mercury - Telekinetically snapped his neck.