Killed by Castiel

“	Jack, I've killed people who didn't deserve it… my friends– I've killed people I loved.	”
	— Castiel to Jack in Tombstone

Beings killed by Castiel.

Angels

Archangels

• Raphael - Exploded at the molecular level while empowered by the souls of Purgatory.

Intelligence Angels

• Ion - Pushed an angel-killing bullet through his right eye to escape Ion and Crowley.

Reapers

• Billie - Stabbed through the back with an angel blade to break her deal with the Winchesters. Reincarnated as the new Death.

Regular Angels

• One of Raphael's Incursion Angels - Stabbed with an angel blade during the Skirmish at Balthazar's Mansion.
• Pharmacist Angel - Stabbed with an angel blade in self-defense.
• Balthazar - Stabbed through the back with an angel blade after discovering Balthazar had betrayed him to the Winchesters.
• Bartholomew - Stabbed in the abdomen with an angel blade in self-defense.
• Alternate Castiel - Stabbed in the abdomen with an angel blade.
• Daniel - Stabbed through the back with an angel blade to save Hannah.
• Efram - Stabbed in the chest with an angel blade.
• Adam's Angel Escorts - Stabbed with an angel blade at Adam Milligan's resurrection site.
• Three of Malachi's Faction - Stabbed with an angel blade after stealing Theo's grace.
• Metatron's Assassins - Killed with an angel blade in self-defense during Operation: Lee Harvey.
• Hael - Stabbed in the chest with an angel blade after being pressured to become her vessel.
• Ishim - Stabbed through the back with an angel blade to save Lily Sunder.
• Raphael Loyalists - Smote in Heaven after declaring himself "the new God."
• Raphael's Spy - Smote in Heaven after declaring himself "the new God."
• Jonah - Stabbed in the abdomen with an angel blade.
• Rachel - Stabbed with an angel blade in self-defense.
• Samandriel - Stabbed in the stomach with an angel blade while under the control of Naomi.
• Theo - Throat slit and grace absorbed then smote.
• Zachariah's Foot-Soldiers - Stabbed through the neck and in the back respectively with an angel blade in order to save Sam and Dean Winchester.
• One of Zachariah's Guards - Stabbed with an angel blade outside the Green Room.

Rit Zien

• Ephraim - Stabbed in the chest with an angel blade.

Nephilim

• Jane - Stabbed through the neck with an angel blade and cut out her heart for Metatron's spell.

Demons

Princes of Hell

• Dagon - Incinerated while empowered by Jack.

Regular Demons

• Crowley's Assassins - Smote to protect the Winchesters and Bobby Singer from an attack.
• Castiel and Lucifer's Attackers - Killed alongside Lucifer in Crowley's old lair.
• Castiel's Captive - Tortured for information on the location of Cain then stabbed through the chest with an angel blade.
• Two of Claire's captors - After taking Claire Novak as his vessel briefly, Castiel smote two of her captors.
• Meg's Captors - Smote at the Murray Hotel while rescuing Meg.
• Bunker Incursion Demons - Smote one to save Sam's life. Killed three others alongside Sam and Gabriel.
• Dipper - Smote in Crowley's old lair after being released from his cell by Lucifer.
• Ellsworth - Forced back into his vessel and then smote so that he could not tell the Winchesters that Crowley is alive.
• Ellsworth's Hunters - Two demons capturing monsters for Elsworth who were smote by Castiel to keep the Winchesters from finding out the truth about Crowley's survival.
• Three Tablet Hunters - Smote two, stabbed a third with an angel blade.
• One Iowa Factory Guard - Smote while rescuing Kevin Tran and the future Prophets.
• Monster Prison Guards - Killed when Castiel destroyed Crowley's Monster Prison and all inside it.
• One of Dean's Captives - Smote to save Dean's life.
• Pestilence's assistant - Stabbed in the abdomen with the demon-killing knife after defeating Pestilence.
• Marcus - Smote by Castiel at the Northern Indiana State Hospital to save Sam Winchester.
• Demon Medics - Smote by a memory-less Castiel outside the Northern Indiana State Hospital.
• Hundreds of demons - As an angel, Castiel has killed hundreds of demons over the millennia.

Monsters

Djinn

• Brigitta - A Djinn held prisoner by Crowley in his prison when Castiel slaughtered the prison's inhabitants.
• Several members of a Syrian Djinn pack - Killed by Castiel during his quest for Fruit of the Tree of Life.

Leviathans

• Dick Roman - Briefly restrained so Dean could stab Dick through the neck with the Bone of Righteous Mortal Washed in the Three Bloods of Fallen.

Rugaru

• Unnamed Rugaru - One of the prisoners in Crowley's Monster Prison killed by Castiel when he killed all of the monsters within the prison..

Jefferson Starships

• Around a dozen Jefferson Starships - Blasted with holy white light.
• Cop Jefferson Starship - Decapitated by Castiel with a machete before it could attack Bobby Singer.
• Prisoner Jefferson Starship - Brutally tortured by Castiel for Eve's location and then decapitated.

Vampires

• Lenore - Smote at her request.
• Unnamed Purgatory Vampire - Smote while fighting alongside Dean and Benny Lafitte.

Werewolves

• One Marina Werewolf - Stabbed in the heart with an angel blade.

Zombies

• An unnamed Croatoan zombie - Decapitated with a shotgun blast to save Sam's life during the Raid on Niveus Pharmaceuticals.

Other Monsters

• Crowley's Monster Prison - Killed all of the monsters within the prison at the Winchesters' request.

Humans

Hunters

• Hundreds of Dean Winchester clones - Killed in various ways by Castiel as part of his training under Naomi.

Vessels

• Alfie - Killed along with Samandriel by Castiel.
• Alternate Jimmy Novak - Killed along with the alternate Castiel by Castiel.
• Balthazar's vessel - Killed along with Balthazar by Castiel.
• Bartholomew's vessel - Killed along with Bartholomew by Castiel.
• Efram's vessel - Killed along with Efram by Castiel.
• Ephraim's vessel - Killed along with Ephraim by Castiel.
• Ion's vessel - Killed along with Ion by Castiel.
• Ishim's vessel - Killed along with Ishim by Castiel.
• Jonah's vessel - Killed along with Jonah by Castiel.
• Gloria Lewellen Jacobson - Killed along with Hael by Castiel.
• Ann Morton - Killed along with the demon possessing her by Castiel.
• Raphael's second vessel - Killed along with Raphael by Castiel.
• Wendy Rice - Killed along with the demon possessing her by Castiel.
• Theo's vessel - Killed along with Theo by Castiel.
• Numerous other vessels - Killed along with the angels and demons possessing them by Castiel.

Other

Four Horsemen of the Apocalypse

• Pestilence - Cut off his ring with the demon-killing knife, leaving him permanently incapacitated.