Staite is best known for playing Kaylee Frye on Firefly and Serenity.
She began modeling and acting as a child. She attended the Vancouver Film School and performed at the Vancouver Youth Theatre. She has worked with the Dyslexia Foundation and several AIDS charities.
- Liar, Liar: Between Father and Daughter (1992)
- Are You Afraid of the Dark: " The Tale of Watchers Woods" (1994) as Kelly
- The X Files: "Oubliette" (1995)
- Space Cases (1996) as Catalina
- Flash Forward (1996–1997) as Rebecca 'Becca' Fisher
- Honey, I Shrunk the Kids (1997–1999) as Tiara VanHorn
- Higher Ground (2000) as Daisy Lipenowski
- Da Vinci's Inquest (1998–2001) as Gabriella Da Vinci
- Just Deal (2002) as Laurel
- Firefly (2002–2003) as Kaylee Frye
- Dead Like Me: "Rest in Peace" (2003) as Goth Girl
- Wonderfalls (2004) as Heidi Gotts
- Serenity (2005) as Kaylee Frye
- Stargate Atlantis (2006–2009) as Dr. Jennifer Keller