Parise made his acting debut in 1994 on the television series Sisters where he played the role of Dwayne. After that he entered the Los Angeles theatre scene in a string of plays, including Jerusalem Avenue, written and directed by Christopher Joyce. He then appeared in many short and feature-length films and television series. His films include The Unscarred (2000), Over My Dead Body (2002), 5 Card Stud (2002), Don't Come Knocking (2005), Land of Plenty (2004), Dark Reel (2008), Body Politic (2009), and The Face of Love (2013).
In 2007, he landed a lead role of Tony in Callback: the Unmaking of Bloodstain, directed by Eric M. Wolfson, for which he won three Best Actor awards for his performance. In 2008 Parise wrote, directed, and starred in the short film Vincent & Lucian.
Parise has been active on television. He played Nick on the television series Cupid from 1998-1999, and he has guest-starred on Turks, Millennium, CSI: Crime Scene Investigation, CSI:NY (playing two different characters five years apart), Walker, Texas Ranger, Titans, NYPD Blue, Monk, Judging Amy, The District, Veronica Mars, Party Down, Burn Notice, and Castle.
In 2007, he was cast in Days of Our Lives playing the role of Detective Sullivan in 10 episodes.
Parise joined the cast of General Hospital in 2013, playing the role of bad boy Carlos Rivera. He made his first debut on September 19, 2013 and continued his run through 2016, after which he returned to the series as Carlos' twin brother, Joe Rivera.
Parise also appeared in the final episode of Mad Men, where he played Vince, the guru. Parise uttered the last spoken words of the iconic series.
Recent roles include Wayne in Anna Biller's acclaimed horror-thriller film The Love Witch, Carlos Camacho in the TV Series The Detour created by Jason Jones and Samantha Bee.
Parise is also an artist, who began painting in the year of 1996. He got his book published, called A Decade of Paintings 2000-2010, which contains his work and writings from the people he has painted as well. He exhibits his works in Los Angeles galleries and art/music festivals throughout California. He also performed the drumbrella with the William Earth Harp Ensemble on the 2012 season of America's Got Talent where they came in 3rd.