Immunity

Immunity is a being's resilience or total impervious nature to supernatural powers, objects, effects, or forces that affect other members of its species. It appears that a creature's age, power level, and/or rank within its species hierarchy dictates if it is immune to its species' weaknesses and to what degree it is immune.

Characters with Immunity

• Sam Winchester - He is completely immune to Croatoan Virus and demonic photokinesis. Sam is initially susceptible to Lilith's powers, but drinking demon blood he gained complete immunity. While Death was bound to him, Sam was temporarily immune to and incapable of dying.
• Dean Winchester - He is completely immune to being made a Rabid due to the influence of the Darkness. While imbued with the power of the Mark of Cain, he became completely immune to Gaelic Obliteration Spell. Dean is initially susceptible to Abaddon's powers, but holding The First Blade he gained completely immunity. While Death was bound to him, Dean was temporarily immune to and incapable of dying.
• Bobby Singer - While Death was bound to him, Bobby was temporarily immune to and incapable of dying.
• Lily Sunder - Lily has displayed an immunity to angelic abilities.
• Angels
  • Castiel (formerly) - While imbued with the power of the 30-40 million souls of Purgatory, he became completely immune to angel blades and angel wards.
  • Archangels - Lucifer is completely immune to Metatron's spell and angel blades. He has limited immunity to The Colt, and was immune to death while Death was bound to him. Michael, Raphael and Gabriel also have some degree of immunity to these angelic weaknesses.
• Nephilim
  • Jack is completely immune to angel blades, angel banishing sigils and angel wards despite possessing angelic heritage. He was also immune to the Ma'lak Box, a coffin designed to keep any creature locked inside, especially an Archangel. However Jack can be weakened by very heavy angel warding.
• Demons
  • Abaddon was completely immune to exorcism rites and hallowed ground. The demon-killing knife and holy fire could harm her painfully, and the latter could destroy her vessel, but neither could kill her. As a Knight of Hell, she is supposed to only have only known one fatal vulnerability, the First Blade when wielded by someone bearing the Mark of Cain. She also displayed partial immunity to holy water.
  • Alastair was completely immune to hallowed ground, the smiting power of average angels, and iron. He had limited immunity to the demon-killing knife, Salt and Holy water.
  • Astaroth may have been immune to iron.
  • Azazel was immune to holy water and hallowed ground.
  • Cain was completely immune to the demon-killing knife and the angelic white light. As observed above, Knights of Hell are supposed to have only one fatal weakness, the First Blade when wielded by someone bearing the Mark of Cain, so it can be presumed that Cain was also immune to angel blades and angelic smiting. He also displayed partial immunity to the devil's trap as shown in the double fact that he stated the trap couldn't hold him long and that he retained at least a measure of his super strength and his telekinesis. All of his other powers seemed bound, however.
  • Crowley was immune to hallowed ground and he had higher than average resistance to holy water and to Rowena's demon-killing spell.
  • Dean - As a Knight of Hell, Dean was supposed to be immortal and immune to most forms of demon-slaying, except for the First Blade when handled by someone bearing the Mark of Cain. He also displayed partial immunity to holy water.
  • Lilith is immune to hallowed ground and possibly to holy water. She was at first completely immune to Sam's powers, but later lost this immunity when Sam got stronger by binging on demon blood. She's also displayed partial immunity to the devil's trap, in that she retains some of her abilities, such as telekinesis and terrakinesis, and is able to employ them to quickly expel a devil's trap inserted into her vessel's body. It can be supposed that she is immune to angel smiting, since this is the case of Alastair, a fellow white-eyed demon who is Lilith's inferior in both rank and strength.
  • Meg was immune to hallowed ground.
  • Ramiel was wholly immune to angel blades and the demon-killing blade. He is also the only demon to display perfect immunity to devil's traps.
  • Ruby was immune to hallowed ground.
  • Samhain was completely immune to iron. He resisted Sam's psychic exorcism better than other demons Sam had faced until then, but he was ultimately overcome by it.
  • Sam Winchester - Sam is completely immune to the Croatoan Virus, and also to demons' powers when he feeds on the blood of people being used as vessels by demons. He is initially susceptible to Lilith's powers, but quickly develops complete immunity to them.
• Ghosts
  • Jacob Karns - He is completely immune to hallowed ground and has limited immunity to salt.
  • Isabella - She has Immunity to hallowed ground.
  • Hugo Moriarty - He has limited immunity to iron.
• Leviathans and Eve - Leviathans and Eve are immune to angelic powers, since they can block them.
  • Dick Roman - He has limited immunity to Borax.
  • Edgar - He has limited immunity to Borax.
• Monsters
  • Alpha Shapeshifter - He is completely immune to silver.
  • Alpha Vampire - He has some degree of immunity to dead man's blood.