The Arrival of Famine was a conflict between the Horseman Famine against Team Free Will.
Battle[]
A small town goes nuts and starts murdering themselves and each other mercilessly giving into their destructive hungers. Based on the enochian marks on the victims' hearts, Castiel is confident the cupid has gone rogue. Castiel corners cupid at the wall who swears he isn't the killer, and was only making people fall in love for special bloodlines. The brothers set a soul free and Castiel said his huger is the biggest clue of all: Famine. Famine manifests and the chaos spreads more aggressively. He reveals to Dean he is dead inside, and Sam exorcises the demons Famine devoured, knocking him out and they take his ring.
Aftermath[]
The concept of famine is still a constant in the world and can't be gotten rid of that easy even though they put down Famine incarnate. Sam detoxes from the demon blood and Dean begs from a higher power to help.