In Hammer of the Gods, in order to try to confort the rest of a group of pagan gods the norse god Odin mentions that "The Great Serpent" child of Loki, Jörmungandr will rise up and he will then be killed by his grandson, the demigod Fenrir, during Ragnarok, although he appeared to be in peace with what he believed was his destiny.
In Remember the Titans, Sam and Dean encounter a demigod named Oliver, who is the son of of the proto-god Prometheus. He had the same curse as his father, which was to die every day only to be brought back, a curse put on Prometheus by Zeus. The curse was lifted by the death of Zeus.
In Sharp Teeth, a cult of werewolves known as the The Maw of Fenris worshiped the Norse demigod Fenrir under the title Fenris. They believed that he would bring about werewolf domination of the world when Ragnarok occurred.
In Unfinished Business, after killing the Prince of Hell Asmodeus, the archangel Gabriel hunts the Norse god Loki and his demigod sons Fenrir, Narfi and Sleipnir for revenge as they had captured Gabriel and sold him to the Prince of Hell in the first place. Low on power, Gabriel uses specially-crafted wooden swords to kill the four with some help from Sam and Dean Winchester.
In The Gamblers, the manager of the Roman goddess of luck Fortuna's pool hall is her son Pax. Pax, who appears to have no real powers of his own, is revealed to be a demigod by Fortuna with a human father. As a result, she states that Dean could probably kill Pax with an angel blade since he's half human and dismisses the threat to her son as irrelevant as she can simply make more children. Dean ultimately decides to release Pax rather than continue to use him as a hostage or to kill the demigod.
In conversation with the Winchesters, Fortuna mentions that she helped the legendary heroes in the past like the three demigods Hercules, Gilgamesh and Cú Chulainn, as well as the human king Gilgamesh in the past.
- Jörmungandr (mentioned only, status unknown)
- Fenrir (deceased)
- Hercules (mentioned only, status unknown)
- Narfi (deceased)
- Sleipnir (deceased)
- Cú Chulainn (mentioned only, status unknown)
- Gilgamesh (mentioned only, status unknown)
- Season 2
- Tall Tales (mentioned only)
- Season 5
- Season 8
- Season 9
- Season 13
- Season 14
- Season 15
- Fenrir has the most lore about him, out of all the on-screen demigods. In contrast, Oliver has none since he is only a young boy when the Winchesters meet him.
- While most demigods on the show have powers of their own, Pax appears to possess none despite being the son of Fortuna. Fortuna even implies that Pax can be easily killed since he has a human father.
- While Oliver and Pax are known to have a human as one of the parents, the other demigods in the show may have been created through their god parent mating with different species, possibly monsters. Fenrir, Narfi and Sleipnir are referred to as "god-begotten monsters" as well as demigods, suggesting that they were hybrids between pagan deities and some unidentified form of monster.
- The earliest recorded use of the term "Demigods" occurs in texts attributed to the archaic Greek poets Homer and Hesiod. Both wrote that demigods who demonstrated "strength, power, good family, and good behavior" were termed "Heroes", and after death they could be called by Hemitheoi, a process that has been referred to as "heroization". Pindar also used the term "demigods" frequently as a synonym for divine "heroes".
- In classical mythology, Hercules (the one Fortuna mentioned) was the Roman equivalent of the Greek divine hero Heracles, who was the son of the chief pagan deity Zeus (Roman equivalent Jupiter) and the mortal Alcmene.