Curtis is best known for his portrayal as Booger in the Revenge of the Nerds movies, as Herbert Viola on Moonlighting, as famed record producer Ahmet Ertegün in the film Ray, for voicing the titular character in the show Dan Vs, as well as Schmuely "Snot" Lonstein in the animated sitcom American Dad. He is also the co-host of the TBS reality television competition series King of the Nerds and was in the 2010 Sitcom Hot in Cleveland as Clark.
- Curtis is a self-proclaimed nerd.
- Curtis once joked that the only way to stay alive on Supernatural was to play a character everyone wanted dead.
- This is consistent with Metatron's fate, as he dies shortly after being redeemed.
- He also played as Justin Russo's pimple on Wizards of Waverly Place (Season 1, Episode 10).