User blog comment:Savannah Star/Things that I'd love to see in "Supernatural" that probably won't happen./@comment-4554525-20121114001551/@comment-3481504-20121114004830

Answer to question #1. There is no biological or family relation; Eve was killed with some other than The Bone of a Righteous Mortal Washed in the Three Bloods of the Fallen.

Answer to question #2. Dunno, we're gonna have to wait and see.

Answer to question #3. God never came into existence - He always was and always will be. Eve I'm not sure of, but the 3 Horsemen - War, Pestilence and Famine - appeared as their representations became apart of the Universe. The war in Heaven conceived War, the Leviathans appetite instigated Famine, and human's vulnerability to illness produced Pestilence.

Answer to question #4 Well, yes. God. But other than that, no, Death can kill anything.