User blog comment:Fusedtwilight/Lucifer and his Mark of Cain/@comment-9249716-20151005192158

If we had to go by what the overall story arc has said, then Lucifer passed the mark on, but that did not mean the effects left him because the mark was not destroyed. Lucifer passed it to Cain, who became the most powerful demon made by Lucifer. Cain passed it on to Dean. But at no point was the mark removed.