User blog comment:EmpyreanSmoke/Supernatural Q&A/@comment-27457157-20150905031539/@comment-24834479-20150907234426

Yes, I believe they can.

There are most likely other magic users than just witches,

I'm not sure if he is the alpha, but he is probably a strong werewolf.

Yes, they exist.

Can't help you there! 😁

No, I don't think God needs sacrifice to gain power.

Possibly if a Cambion and a Nephilim had a child.