User blog comment:ImperiexSeed/It's Battle Time!/@comment-3045936-20120214171604/@comment-3481504-20120215034203

Here's the thing...

To what the Colt can or can't kill, seems to depend on Samuel's understanding. As a human, there's no way Colt could possibly understand Archangels, which is why Lucifer cannot be killed by it. With that said, Zachariah is a being with four heads and six wings, and there's no way Samuel could possibly understand such an complexion.

Zachariah being a Seraph, could at least decapitate one, though maybe not fully killing it. Also, I doubt Seraphs derive their powers from Heaven, therefore couldn't be "unplugged"