User blog comment:CROWMETA13/Ending of season 11/@comment-109.193.194.114-20160413124212

I think they will use another hand of God to banish Amara into the void. In heaven, Lucifer mentioned that he knows a way how to seal Amara away once and for all. So I guess it all depends on Dean. He has to betray Amara in order to seal her away for ever. She definitely won't die, she survived incredible attacks (angels smiting using all of heaven's energy, god + archangels, Lucifer + hand of God) - but being sealed away for ever might be even worse.