User blog comment:Absinthemindedx/How will it end?/@comment-5120709-20120527032926

I don't think they'll die. Supernatural is inspired by Westerns, and most of them end with the cowboy going off in search of more adventures. My guess is that it'll end similar to Season 2, with them having beaten the main bad guy but going off because, as they say, they "have work to do"