User blog comment:Ikmeos/Demonic power level, powerful weapons and the primordial siblings./@comment-91.89.184.182-20170228153932/@comment-146.198.136.113-20170228171135

Idk, but on the Scythe's page on this wiki, it says it can kill/reap anything. Hell, Death even said that he would reap God, so yeah, I'm pretty sure he can reap humans and Nephilim with it.