User blog comment:Gabriel456/Would Soulless Sam be immune to Famine/@comment-3045936-20120809170409

I doubt it as Castiel was affected and as an Angel he has no soul. (However, I say that it was Jimmy the vessal that was affected as Castiel said it was Jimmy's hunger he just got affected by it.) But Dean at the time had a (nothingness) inside of him according to Famine that couldn't be filled and called that part of him already dead. I think Souless Sam hunger would be more of showing everyone he is better soulless like as a hunter, than Sam with a Soul to where it would drive him crazy.