User blog comment:MrAnonymous/The Alphas?/@comment-3045936-20120513202429

The alpha shapeshifter was killed by crowley so he is gone. I would say that the Alpha Vampire is the only one alive that Crowley and Sam and Dean know of. There would have to be an Alpha for the Dragons, Wraiths, Shojus, Okamis, Wendigo, and many others unless in 10,000 years they all died. As any monster than is not an angel, fairy, god, demon, or reaper isn't of Eve's making. As well as spiritual beings like ghosts, vengeful spirits, and hellish beasts, like the hellhounds of the whore.