User blog comment:Anonyme Tät/Lilith's Crook vs Mark of Cain/@comment-5619706-20200220170932

Lilith is the most powerful demon, yes, but people seem to forget the Mark of Cain has ties to God and the Darkness. Both entities are more powerful than any demon or archangel. In any case, this seems to be a question of offense (Lilith being empowered by hell's souls) vs defense (invulnerability because of the Mark).

We don't know what the crook's effect will be on the bearer of the Mark (Abaddon's telekinesis against Dean was rendered useless). Unless Lilith becomes incredibly powerful that she could remove the Mark the same way Death, God or the spell Rowena used could.