User blog comment:Twilight Despair 5/New Plots/@comment-86.159.94.164-20180718200833

Hmm off the top of my head perhaps something along these lines.

1. Possible alliance between Heaven and the Pagans what with heavens weakened state and need for a new power sorce. Afterall if heaven falls the resulting chaos and death would rob the pagans of potential food and followers. So perhaps have Jack, Sam and Cas (not sure about Dean at this point) reach out to the Pagans for help. That in return for lending them some of their power Heaven would ease up on the attacks against the Pagans.

2. Nylarthotep comes from the Empty: Now bare in mind my Lovecraft is rusty but, I got a bit of an Azathoth vibe from the Cosmic Entity. So after the whole incident with Cass and the fact there is a chance more will come looking for the empty the Cosmic entity sends its "son" and enforcer to Earth to wipe out everyone who is a risk to its slumber.