The Devil You Know

Summary
No major plot summary has yet been released for this episode as of yet, apart from the revelation of the identity of the central antagonist of the episode, the final of The Four Horsemen of the Apocalypse, Pestilence (confirmed to be portrayed by Matt Frewer). As Pestilence controls the spread of viruses and diseases, it has been implied that he may have something to do with spreading the Croatoan virus as part of Lucifer's endgame for mankind.

Major Characters

 * Dean Winchester
 * Sam Winchester
 * Castiel
 * Pestilence

Trivia

 * Matt Frewer is confirmed to portray Pestilence.