Brian Wilcox

Brian was a film student whose roommate and best friend, Michael, was dating Kate, a girl for whom Brian also had feelings. After Mike was bitten by a werewolf and subsequently began developing his werewolf abilities, Brian began to envy him, having hidden behind Mike for so long. Brian tried to convince Mike to bite him, but he refused, warning Brian that a werewolf's life was a curse, not a gift.

The two's relationship began to steadily decrease, with Brain originally filming Mike, and upon learning he had killed someone, began antagonizing him on it and calling him a monster. Eventually, Mike threw Brian across the room in a rage which finally destroyed their friendship. Eventually Brian managed to track down the original werewolf, a college professor named Ludensky. Using a silver knife and and threatening to expose him, he blackmailed him into turning Brian into a werewolf. He then tipped off Sam and Dean that the professor was the werewolf which led to the professor's death by their hands.

Upon returning to Mike and Kate as a werewolf, the three got into an argument, resulting in a fight between him and Mike. During the fight, Brian managed to stab Mike with his silver knife killing him. He turned to Kate, and thinking she would understand if she saw things the same way he did, bit her and turned her into a werewolf. Kate pretended to join Brian before ambushing him and using her new powers to tear him to shreds, thus killing him.