User blog comment:Ikmeos/Demonic power level, powerful weapons and the primordial siblings./@comment-79.115.67.195-20170228123723/@comment-146.198.136.113-20170228180935

Yes, I think that the Colt cannot kill 5 beings in existance, since Lucifer referred to himself as one of the five. (5x10, "There's five things in all creation the Colt can't kill and you're talking to one of them."  But it's just a theory.  It should definitely be able to kill angels though.

It took the combined strength of God and the four Archangels to weaken Amara enough to seal her away. In We Happy Few (11x22), God said that with just Him and Lucifer, they would lose. So they invited demons angels, witches and that Diminishing spell to the party.