User blog comment:EmpyreanSmoke/Supernatural Q&A/@comment-3976024-20150929155825/@comment-24834479-20150929234550

1. It was most likely created at the same time as Lucifer's cage.

2. I doubt it would have been able to undo the first curse, but it would probably make thr physical appearance disappear.

3. Lucifer had to pass the mark to another before being put in his cage.

4. Sorry, I just meant wendigos, not amazons too.

5. God created the physical universe after he came into existence.