User blog comment:EmpyreanSmoke/Supernatural Q&A/@comment-27006668-20151026220942/@comment-24834479-20151026234653

1. It's a possibility, but I think Death would rather keep the natural order and take Sam to the afterlife he was meant to go to.

2. Jesus was not mortal. Only some supernatural weapons can kill him.

3. It is possible that higher angel beings could smite Jessie.