User blog comment:T95/Michael (Alternate Reality) vs Thanos (Marvel Cinematic Universe/@comment-1031724-20180519172236

All depends on whether Thanos has the Gauntlet or not.

Thanos is very powerful, but he is not invincible. Iron Man was able to scratch him, Spiderman beat him up (I think with help from Doctor Strange's portals, I can't remember), and Thor nearly killed him, though with a weapon described as one that could kill Thanos and it had to be forged by Peter Dinklage like the Gauntlet and the hammer.

Without the Gauntlet? Thanos might have a chance if Michael was in his original vessel. But possessing Dean, Michael would probably win.

Ironically I compared Thanos to Lucifer as the long-running villains, except they actually killed Lucifer off and probably won't do the same with Thanos.