Jane

Jane was a Nephilim, the product of an angel and a human reproducing. She worked as a waitress. Apparently, she was the only Nephilim left in existence. She was killed by Castiel.

Physical Appearance
She appeared to be a woman aged 20-30. She had reddish-brown hair and light blue-green eyes. Her eyes glowed gray during the fight with Metatron and Castiel.

Powers and Abilities
Her angelic heritage endowed her with three distinct abilities that made her superior to humans in terms of physical prowess but inferior to most Angels. However, it cannot be known if she showed her full power during her encounter with Castiel and Metatron.
 * Super strength - As a Nephilim, she bore enough strength to toss low-level angels around. She was also able to throw around a wounded Seraph.
 * Invulnerability - She possessed a high tolerance for pain and could withstand attacks from a high-ranking angel like the Seraph Castiel.
 * Astral perception - She could perceive the true form of angels.

Vulnerabilities

 * Angel Blade - Castiel used his angel blade to kill her.
 * Holy Fire - (unconfirmed) likely her angelic heritage gives her this weakness.
 * Death's Scythe - It can reap anything in existence.

Season 8
Jane first appeared as a waitress to Castiel and Metatron. Metatron explained her Nephilim heritage and that in order for the trials to be finished, he must kill her. Castiel did so later, inadvertently triggering the eventual expelling of angels after being tricked by Metatron.

Appearances

 * Season 8
 * Clip Show

Trivia

 * Since the Grigori are the angels who created the Nephlim in lore, and there are still some walking the Earth and interacting with humans, it is possible that Jane is the daughter of a Grigori.
 * Her heart was one of the three ingredients needed to banish all angels from Heaven.
 * She's the first and only Nephilim to appear in Supernatural.