User blog comment:KillRoy231/How did you feel about O Brother Where Art Thou?/@comment-26982641-20151211212146/@comment-89.204.138.152-20151211213650

I think nothing can destroy her, but she has not gained all her former power back yet. Since she is at least equal to God, she could have just killed those angels by thinking it, but how she did it was still really impressive.

I think Lucifer knows how to re-imprison her, but seeing that Lucifer is the bigger threat (despite much less powerful than Amara), Amara will probably kill him sooner or later, since he would be also a threat to Dean.