User blog comment:Noctosphere/Who do you think should be the Big Bad of S12/@comment-1975828-20170529163058

I don't count Toni as a Big Bad. She was a puppet to the organization. She didn't even want to be there, nor be involved with the Winchesters, but she was ordered to.

Everything she did was based on her command, and she took no real pleasure in torturing anyone. She thought Sam was dangerous at first, then treated Mary like a project she was to complete. She helped the Winchesters in the end too, at the cost of her life.

Doctor Hess and Ketch are most certainly Big Bads. Ketch enjoyed the killings he committed, he would even kill more if he believed his boss wouldn't complain. He was virtually Dean's rival too, acting as a polar opposite to who Dean is.

So yeah, I'd personally remove Toni from the list. She was a puppet. Nothing more.