User blog comment:Noctosphere/Who do you think should be the Big Bad of S12/@comment-1975828-20170528160602/@comment-10889355-20170529004644

Dagon is part of the main plot though? Or at least the first plot. She's Lucifer's follower and without her Kelly would've been killed early and Jack would never be born. So yes, she contributed something significant to the plot of the season. She's a secondary antagonist.

Doctor Hess is a major villain. It was made pretty clear that she was the one responsible for sending the British hunters to America to clear out the hunters. She wasn't in a lot of episodes but she is the root of one of the major plots of the season.